In our series "In Practice" our customers describe how they use our digital imaging solutions - such as hardware and software - in their daily laboratory lives. All articles have been published in recommend magazines.


Protons head-to-head and up close
CERN: monitoring superconductors via digital image analysis

CERN, located near Geneva, Switzerland, is building a new proton synchrotron, a circular accelerator for proton particle collisions. There are more than 1200 magnets in use for keeping the protons on course. The superconducting wire used for the magnet coils has an inner filament structure that is inspected via automated particle analysis based on metallographical cross sections.  For the digital acquisition of the microscope images, an Olympus BX51M microscope is used. The digital camera mounted onto the microscope and the image analysis software are by Olympus Soft Imaging Solutions.

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Show it all – right away!
Digital multichannel fluorescence microscopy in developmental biology

Egg formation in the fruit fly is a complex process. In the Department for Zoology/Developmental Biology at the University of Kassel, Germany, we are especially interested in investigating errors that can take place in the maturing egg chamber.  The various imaging methods available with a microscope, such as different fluorescences or Nomarski optics, make only a part of the cell structures visible.  However, these image contents can be merged digitally via a CCD color camera and the analySIS image analysis software by Olympus Soft Imaging Solutions, creating images that "show it all – right away".

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Cell-based genome-wide RNAi screening with the new scan^R Screening Station

In collaboration with the Euopean Molecular Bilogy Laboratory (EMBL), Olymus has developed a fully automated and highly flexible microscope-based screening platform for life science appliactions.

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Modular Microscope-Based Screening Station

Drug discovery has driven our understanding of scientific principles as well as advanced the equipment and processes used to research them. One overriding princple applied to this industry is the drive for more data in less time with fewer overheads. The scan^R Screening Station for Life Science is an instrument with the potential to meet all of these requirements and provide users with advantages over other products on the market.

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Screening Station for Life Science

Cell-based screening and assay development are challenges requiring extremely flexible solutions; no two experiments are the same. Therefore, Olympus has designed the scan^R Screening Station as a highly flexible "optical branch" enabling advanced microscope-based image acquisition and analysis. scan^R was developed into a powerful screening platform with an extremely broad application range on the basis of an experimental screening system designed by the European Molecular Biology Laboratory (EMBL).

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Schnelle Differenzialdiagnose mit elektronenmikroskopischer Elementanalyse

Leberzirrhose hat viele Ursachen. Dazu zählen neben Alkoholmissbrauch und Virushepatitis zwei der häufigsten erblichen Stoffwechselerkrankungen: Hämochromatose mit pathologischer Eisenanreicherung und Morbus Wilson mit pathologischer Kupferspeicherung. Um sie zu unterscheiden, setzt das Institut für Pathologie der Uni Rostock zur Untersuchung von Gewebeschnitten energiefilternde Transmissions-Elektronenmikroskope ein. Dank des eingebauten Energiefilters und Software von Olympus Soft Imaging Soutions für digitale Bildaufnahme und Bildverarbeitung lassen sich damit Elementverteilungsbilder und Energieverlustspektren erzeugen. Diese ermöglichen bereits im Frühstadium eine schnelle Diagnose und damit eine frühzeitige Therapie.

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Elektronenmikroskopie und digitale Bildanalyse im Arbeitsschutz

Asbestfasern können Lungenkrebs auslösen. Auch neuartige Nanopartikel bergen ein hohes Gesundheitsrisiko. Was für Fasern finden sich in einem bestimmten Material? Wie viele Partikel gelangen in die Atemluft? Im Rahmen des Arbeitsschutzes geht die Fachstelle „Gefährliche Arbeitsstoffe“ einer Düsseldorfer Berufsgenossenschaft solchen Fragen nach. Am Transmissionselektronenmikroskop kommt eine MegaView III Digitalkamera und die Bildanalyse-Plattform iTEM zum Einsatz.

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Pyrokohlenstoff-Schichten: Abscheideparameter, Korngrenzen, Kohlenstoffmodifikationen

Pyrokohlenstoff-Schichten finden breite Anwendung in der Industrie. Wichtig ist, ihre physikalischen Eigenschaften gezielt einstellen zu können. Forscher der Universität Karlsruhe untersuchen deshalb die Zusammenhänge zwischen den Herstellungsbedingungen, der Mikrostruktur und den physikalischen Eigenschaften. Dafür setzen sie Licht- und Elektronenmikroskope ein. Für die Mikroskopsteuerung sowie die digitale Aufzeichnung, Verwaltung, Archivierung und Auswertung ihrer Bilder und Spektren nutzen sie Bildanalyse-Software von Olympus Soft Imaging Solutions.

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